黄耀伟

黄耀伟 博士 硕士生导师 博士生导师

 学科:预防兽医学
邮箱:yhuang@scau.edu.cn
通讯地址:广州市天河区五山街道华南农业大学东区实验楼214-3室
教研室:动物传染病教研室


简介


  黄耀伟,男,生物医学工程(动物病毒学方向)博士,教授,博士、硕士生导师。入选国家万人计划科技创新领军人才、科技部中青年科技创新领军人才、国家青年人才引进计划、浙江省特聘专家、杭州市“钱江特聘”专家。浙江省杰出青年基金获得者、中国畜牧兽医学会生物技术学分会常务理事、中国微生物学会病毒学专业委员会委员、黑龙江省兽医免疫学重点实验室学术委员会委员、浙江省农业湘湖实验室生物制造研究院特聘顾问。主要研究方向为动物冠状病毒和戊型肝炎病毒的病原生物学与抗感染免疫。SCI期刊Virology、Virus Research、Veterinary Microbiology编委(Editorial Board Member)、《中国兽医学报》编委。在J Hepatology, Autophagy, mBio, PLoS Pathogens, J Virol, JBC, EMI等本领域主流期刊发表SCI论文110余篇,H指数34,参编病毒学英文权威专著《Fields Virology》第7版章节。获浙江省科学技术奖一等奖2次(分别排名第2和第3)。


教育经历


2000/09 至 2003/03,浙江大学,生物医学工程系,工学博士;

1998/09 至 2000/08,浙江大学,动物科学学院,攻读预防兽医学硕士(后转硕博连读);

1994/09 至 1998/07,南京大学,生物科学与技术系,理学学士


工作经历


2022/08 至今 bat365官网登录,教授/研究员

2013/09 至 2024 浙江大学动物科学学院动物医学系,教授

2011/01 至 2013/08,美国弗吉尼亚理工大学bat365官网登录生物医学与病理生物学系,研究助理教授(Research Assistant Professor)

2008/01 至 2010/12,美国弗吉尼亚理工大学bat365官网登录,研究科学家(Research Scientist)

2003/04 至 2007/12,美国弗吉尼亚理工大学bat365官网登录,博士后


研究领域


猪肠道冠状病毒(PEDV, PDCoV, SeACoV/SADS-CoV)

戊型肝炎病毒(HEV)

其它猪重要致病性病毒及新突发病毒

人用与兽用新型疫苗及抗病毒药物


承担科研项目情况


1. 浙江省杰出青年基金(2014)

2. 留学回国人员启动基金(2015)

3. 国家自然科学基金面上项目(2016)

4. 科技部十三五重点研发计划子课题(2016-2020)

5. 浙江省重点研发计划(2016-2019)

6. 科技部十三五重点研发计划课题(2017-2021) 

7. 国家自然科学基金面上项目(2019)

8. 国家自然科学基金新冠专项项目(2020)

9. 浙江省自然科学基金重点项目(2022-2024)

10. 浙江省尖兵研发攻关计划(2022)

11. 科技部十四五重点研发计划子课题(2021)

12. 国家自然科学基金联合基金重点项目(2023)

13. 国家自然科学基金重大研究计划培育项目(2023)


代表论著(*通讯作者)


(所有发表的SCI文章更新详见https://person.zju.edu.cn/yaoweihuang “研究与成果”栏目)

1. Yang YL, Wang B, Li W, Cai HL, Qian QY, Qin Y, Shi FS, Bosch BJ*, Huang YW*. Functional dissection of the spike glycoprotein S1 subunit and identification of cellular cofactors for regulation of swine acute diarrhea syndrome coronavirus entry. Journal of Virology, 2024, in press.

2. Shi FS, Xie YH, Yang YL, Xu LD, Li JJ, Wang X, Zhu LY, Wang WW, Shen PL, Huang YW*, Li XQ*. Fucoidan from Ascophyllum nodosum and Undaria pinnatifida attenuate SARS-CoV-2 infection in vitro and in vivo by suppressing ACE2 and alleviating inflammation. Carbohydrate Polymers, 2024, 332:121884.

中文介绍:https://baijiahao.baidu.com/s?id=1790025614566978417&wfr=spider&for=pc 

3. Zhao Z, Xu LD, Zhang F, Liang QZ, Jiao Y, Shi FS, He B, Xu P*, Huang YW*. Heat shock protein 90 facilitates SARS-CoV-2 structural protein-mediated virion assembly and promotes virus-induced pyroptosis. Journal of Biological Chemistry. 2023, 299(5):104668.

中文介绍:/2023/0413/c862a342561/page.htm 

4. Liang QZ, Wang B, Ji CM, Hu F, Qin P, Feng Y, Tang YD, Huang YW*. Chicken or porcine aminopeptidase N mediates cellular entry of pseudoviruses carrying spike glycoprotein from the avian deltacoronaviruses HKU11, HKU13 and HKU17. Journal of Virology, 2023, 97:e01947-22.

中文介绍:/2023/0208/c9708a335461/page.htm 

5. Zhang F, Xu LD, Zhang Q, Wang A, Yu X, Liu S, Chen C, Wu S, Jin J, Lin A, Neculai D, Zhao B, Feng XH, Liang T*, Xu P*, Huang YW*. Targeting proteostasis of the HEV replicase to combat infection in preclinical models. Journal of Hepatology. 2023, 78: 704-716.

中文介绍:https://www.scau.edu.cn/2022/1227/c11310a334506/page.htm 

6. Liu Y#, Wang B#, Liang QZ, Shi FS, Ji CM, Yang XL, Yang YL, Qin P, Chen R, Huang YW*. Roles of two major domains of the porcine deltacoronavirus S1 subunit in receptor binding and neutralization. Journal of Virology, 2021, 95:e01118-21. 

中文介绍:https://new.qq.com/omn/20211121/20211121A02IZT00.html 

7. Yang YL, Qin P, Wang B, Liu Y, Xu GH, Peng L, Zhou J, Zhu SJ*, Huang YW*. Broad cross-species infection of cultured cells by bat HKU2-related swine acute diarrhea syndrome coronavirus and identification of its replication in murine dendritic cells in vivo highlight its potential for diverse interspecies transmission. Journal of Virology, 2019, 93:e01448-19.

中文介绍: http://www.sohu.com/a/348071280_749000 

8. Wang B, Liu Y, Ji CM, Yang YL, Liang QZ, Zhao P, Xu LD, Lei XM, Luo WT, Qin P, Zhou J, Huang YW*. Porcine deltacoronavirus engages the transmissible gastroenteritis virus functional receptor porcine aminopeptidase N for infectious cellular entry. Journal of Virology, 2018, 92:e00318-18. 

中文介绍: http://www.virosin.org/Post/Details/PT180410000004iPlRo 

9. Pan Y, Tian X, Qin P, Wang B, Zhao P, Yang YL, Wang L, Wang D, Song Y, Zhang X*, Huang YW*. Discovery of a novel swine enteric alphacoronavirus (SeACoV) in southern China. Veterinary Microbiology, 2017, 211:15-21.

中文介绍:http://www.sohu.com/a/197584550_749000 

ESI高被引论文

10. Huang YW*, Dickerman AW, Pineyro P, Li L, Fang L, Kiehne R, Opriessnig T, Meng XJ*. Origin, Evolution, and Genotyping of Emergent Porcine Epidemic Diarrhea Virus Strains in the United States.  mBio, 2013, 4(5):e00737-13. (*Corresponding author) 

Nature Research Highlights: Chinese origin for US pig virus. Nature 504, 11 (December 05, 2013) doi:10.1038/504011f  http://www.nature.com/nature/journal/v504/n7478/full/504011f.html 

ESI高被引论文

11. Huang YW, Harrall KK, Dryman BA, Opriessnig T, Vaughn EM, Roof MB, Meng XJ. Serological profile of Torque teno sus virus species 1 (TTSuV1) in pigs and antigenic relationships between two TTSuV1 genotypes (1a and 1b), between two species (TTSuV1 and 2), and between porcine and human anelloviruses. Journal of Virology, 2012, 86(19):10628-10639. 

12. Huang YW, Patterson AR, Opriessnig T, Dryman BA, Gallei A, Harrall KK, Vaughn EM, Roof MB, Meng XJ. Rescue of a porcine anellovirus (Torque teno sus virus 2) from cloned genomic DNA in pigs. Journal of Virology, 2012, 86(11):6042-6054.

13. Huang YW, Opriessnig T, Halbur PG, Meng XJ. Initiation at the third in-frame AUG codon of open reading frame 3 of the hepatitis E virus is essential for viral infectivity in vivo. Journal of Virology, 2007, 81(6):3018-3026. 

14. Huang YW, Haqshenas G, Kasorndorkbua C, Halbur PG, Emerson SU, Meng XJ. Capped RNA transcripts of full-length cDNA clones of swine hepatitis E virus are replication competent when transfected into Huh7 cells and infectious when intrahepatically inoculated into pigs. Journal of Virology, 2005,79(3):1552-1558.

15. Book Chapters:

Meng XJ, Huang YW. 2021. Circoviridae and Anelloviridae. In: Fields Virology, 7th Edition (volume 2, chapter 7). David M. Knipe and Peter M. Howley (eds). Lippincott Williams & Wilkins, Philadelphia, PA. pp 197-211.


写给学生的话


珍惜时光,处涸辙以犹欢;主动挖掘真实世界的科学问题,在研究探索中不断超越自我。


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