汤有志（博士），男，1983年6月出生，华南农业大学教授、博／硕士研究生导师，十四五国家重点研发计划首席青年科学家，广东省自然科学基金杰出青年基金获得者。长期从事新兽药相关教学科研工作。2004年，吉林大学化学学院高分子材料与工程专业本科毕业，2004-2009年，于吉林大学有机化学系攻读博士学位，获博士学位。博士期间从事抗氧化剂的设计、合成及构效关系研究，在药物化学研究方面积累了丰富的经验。2009年就职于华南农业大学，主要的研究领域是抗流感病毒药物、非甾体抗炎药及半合成抗生素的分子设计、合成与活性研究工作。主持十四五国家重点研发计划青年项目(2021YFD1800600)、国家自然科学基金面上项目、青年基金(批准号：31672602、31001085)、国家重点研发计划子课题(2016YFD0501307)、教育部博士点新教师基金(批准号：20104404120013)、广东省自然科学基金杰出青年项目(批准号：2019B151502002)、广东高校优秀青年创新人才培育项目(育苗工程) (批准号：LYM09032)、广州市珠江科技新星项目(批准号：2014J2200042)、华南农业大学校长基金(批准号：5500-K11046)。2011年入选“华南农业大学骨干青年教师”，2012年入选华南农业大学广东省高等学校“千百十工程”第七批校级培养对象，2014年入选广州市珠江科技新星，2019年获广东省自然科学基金杰出青年项目，2021年获十四五国家重点研发计划青年科学家项目，2021年作为核心成员入选国家自然科学基金委创新群体。

2004年9月-2009年7月，吉林大学，化学学院，研究生/博士学位，导师：刘在群教授

2000年9月-2004年7月，吉林大学，化学学院，本科/学士学位

•2019年1月至今，华南农业大学，教授

•2017年4月-2017年12月，国家自然科学基金委，计划局，借调

•2014年5月-2015年9月，加州大学旧金山分校，药学院，访问学者

•2013年12月-2018年12月，华南农业大学，副教授、青年教授

•2009年7月-2013年12月，华南农业大学，讲师

·抗菌、抗炎、生物抗氧化剂等活性分子的设计、合成及活性机制研究

国家重点研发计划青年科学家项目（2021YFD1800600），2021-2025，主持

广东省自然科学基金杰出青年基金（2019B151502002），2019-2023，主持

国家自然科学基金创新研究群体（32121004），2022-2026，核心成员

国家自然科学基金 (31672602) ，2017-2020，主持

·国家重点研发计划子课题(2016YFD0501307)，2017-2020，主持

·广州市珠江科技新星 (2014J2200042)，2014-2017，主持

·国家自然科学基金 (31001085) ，2011-2013，主持

·教育部博士点新教师基金(20104404120013) ，2011-2013，主持

·广东高校优秀青年创新人才培育项目(育苗工程) (LYM09032) ，2009-2011，主持

·华南农业大学校长基金(5500-K11046) ，2011-2013，主持

1.Dingyi Shen, Songpo Duan, Yuhan Hu, Jintong Liang, Youzhi Tang*. “Antibacterial activity and synergistic antibiotic mechanism of phenolic compounds against methicillin-resistant Staphylococcus aureus” Phytotherapy Research, 2022, accepted (DOI: 10.1002/ptr.7629)

2.Zhuo-Qi Zhang, Jie Liu, Guang-Yu Zhang, Bo Li, Kang Li, Zhen Jin, Xu Bai*, You-Zhi Tang*. “Design, synthesis, antibacterial activity evaluation and molecular docking study of pleuromutilin derivatives bearing amide side chains” Chemical Biology & Drug Design, 2022, 100: 564-579. (DOI: 10.1111/cbdd.14106)

3.Yuhan Hu, Fang Chen, Kexin Zhou, Zhe Zhang, Fei Li, Jianfeng Zhang, Youzhi Tang* and Zhen Jin*. “In vitro and in vivo Antibacterial Activity, Toxicity and Resistance Analysis of Pleuromutilin Derivative Z33 against Methicillin-Resistant Staphylococcus aureus” Molecules, 2022, 27(15): 4939. (DOI:10.3390/molecules27154939)

4.Qi Wang, Jie Liu, Zi-Dan Zhou, Ke-Xin Zhou, Fei Li, Qi-Wen Zhang, Shou-Kai Wang, Wei Wang, Zhen Jin*, You-Zhi Tang*. “Design, synthesis, biological evaluation and molecular docking studies of novel pleuromutilin derivatives containing nitrogen heterocycle and alkylamine groups” Journal of Enzyme Inhibition and Medicinal Chemistry, 2022, 37, (1): 2078-2091. (DOI: 10.1080/14756366.2022.2104267)

5.Shou-Kai Wang, Ting-Xiao Chen, Wei Wang, Ling Ling Xu, Yu-Qing Zhang, Zhen Jin, You-Bin Liu*, You-Zhi Tang*. “Aesculetin exhibited anti-inflammatory activities through inhibiting NF-кB and MAPKs pathway in vitro and in vivo” Journal of Ethnopharmacology, 2022, 296: Article 115489. (DOI: 10.1016/j.jep.2022.115489)

6.Fei Chai, Jun Wang, Ke-Xin Zhou, Shou-Kai Wang, Ya-Hong Liu, Zhen Jin*, You-Zhi Tang*. “Design, synthesis and biological evaluation of novel pleuromutilin derivatives possessing 4-aminothiophenol linker as promising antibacterial agents.” Bioorganic Chemistry, 2022, 126: Article 105859. (DOI: 10.1016/j.bioorg.2022.105859)

7.Xiao Wang, Rui Wang, Zhao-Sheng Zhang, Guang-Yu Zhang, Zhen Jin, Rong Shen, Dan Du*, You-Zhi Tang*. “Semisynthetic Pleuromutilin Antimicrobials with Therapeutic Potential against Methicillin-Resistant Staphylococcus aureus by targeting 50S Ribosomal Subunit”. European Journal of Medicinal Chemistry, 2022, 237: Article 114341. (DOI: 10.1016/j.ejmech.2022.114341)

8.Han-Qing Fang, Jie Zeng, Shou-Kai Wang, Xiao Wang, Fang Chen, Bo Li, Jie Liu, Zhen Jin, Ya-Hong Liu, You-Zhi Tang*. “Discovery of Novel Pleuromutilin Derivatives as Potent Antibacterial Agents for the Treatment of MRSA Infection”. Molecules, 2022, 27(3): 931. (DOI:10.3390/molecules27030931)

9.Zhe Zhang, Zhao-Sheng Zhang, Xiao Wang, Gao-Lei Xi*, Zhen Jin, You-Zhi Tang*. “A click chemistry approach to pleuromutilin derivatives, evaluation of anti-MRSA activity and elucidation of binding mode by surface plasmon resonance and molecular docking”. Journal of Enzyme Inhibition and Medicinal Chemistry, 2021, 36(1): 2087-2103. (DOI: 10.1080/14756366.2021.1977931)

10.Bo Li, Zhe Zhang, Jian-Feng Zhang, Jie Liu, Xiang-Yi Zuo, Fang Chen, Guang-Yu Zhang, Han-Qing Fang, Zhen Jin, You-Zhi Tang*. “Design, synthesis and biological evaluation of pleuromutilin-Schiff base hybrids as potent anti-MRSA agents in vitro and in vivo”. European Journal of Medicinal Chemistry, 2021, 223: Article 113624. (DOI: 10.1016/j.ejmech.2021.113624)

11.Xiang-Yi Zuo#, Hong Gao#, Mei-Ling Gao, Zhen Jin, You-Zhi Tang*. “Antibacterial activity of a promising antibacterial agent: 22-(4-(2-(4-Nitrophenyl-piperazin-1-yl)-acetyl)-piperazin-1-yl)-22-deoxypleuromutilin”. Molecules, 2021, 26(15): 3502 (DOI:10.3390/molecules26123502) 

12.Jie Liu, Guang-Yu Zhang, Zhe Zhang, Bo Li, Fei Chai, Qi Wang, Zi-Dan Zhou, Ling-Ling Xu, Shou-Kai Wang, Zhen Jin*, You-Zhi Tang*. “Design, synthesis, in vitro and in vivo evaluation against MRSA and molecular docking studies of novel pleuromutilin derivatives bearing 1, 3, 4-oxadiazole linker”. Bioorganic Chemistry, 2021, 112: Article 104956. (DOI: 10.1016/j.bioorg.2021.104956)

13.Chuang Ma#, Fang Chen#, Xin Song, Ming Chen, Lili Gao, Peijun Wang, Jialun Wen, Zhou Yang, Youzhi Tang*, Kui Zhao*, Shengzhong Liu*. “Centimeter-Sized Molecular Perovskite Crystal for Efficient X-Ray Detection”. Advanced Functional Materials, 2021, 31(21): Article 2100691. Online. (DOI:10.1002/adfm.202100691)

14.Si-Yu Huang, Xiao Wang, Ding-Yi Shen, Fang Chen, Guang-Yu Zhang, Zhe Zhang, Kang Li, Zhen Jin, Dan Du, You-Zhi Tang*. “Design, synthesis and biological evaluation of novel pleuromutilin derivatives as potent anti-MRSA agents targeting the 50S ribosome”. Bioorganic Medicinal Chemistry, 2021, 38: Article 116138. (DOI:10.1016/j.bmc.2021.116138.)

15.Xiao Wang, Ling-Ling Xu, Xiang-Yi Zuo, Jia-Wen Lin, Zhen Jin, Rong Shen, Dan Du*, You-Zhi Tang*. Rapid detection of the New Delhi metallo-β-lactamase (NDM) gene by recombinase polymerase amplification. Infection, Genetics and Evolution, 2021, 87: Article 104678. (DOI:10.1016/j.meegid.2020.104678)

16.Guang-Yu Zhang, Zhe Zhang, Kang Li, Jie Liu, Bo Li, Zhen Jin, Ya-Hong Liu, You-Zhi Tang*. Design, synthesis and biological evaluation of novel pleuromutilin derivatives containing piperazine and 1,2,3-triazole linker. Bioorganic Chemistry, 2020, 105: Article 104398. (DOI: 10.1016/j.bioorg.2020.104398)

17.Aparna Sundaram, Chun Chen, Nilgun Isik Reed, Sean Liu, Seul Ki Yeon, Joel McIntosh, You-Zhi Tang, Hyunjun Yang, Marc Adler, Richard Beresis, Ian B. Seiple, Dean Sheppard, William F. DeGrado, Hyunil Jo. “Dual antagonists of α5β1/ αvβ1 integrin for airway hyperresponsiveness”. Bioorganic & Medicinal Chemistry Letters, 2020, 30(22): 127578. (DOI: 10.1016/j.bmcl.2020.127578)

18.Fang Chen, Meng-Chao Wei, Yi-Dan Luo, Zhen Jin*, You-Zhi Tang*. Synergistic effect of a pleuromutilin derivative with tetracycline against Streptococcus suis in vitro and in the neutropenic thigh infection model. Molecules, 2020, 25(15): 3522. (DOI: 10.3390/molecules25153522)

19.Zhe Zhang, Kang Li, Guang-Yu Zhang, You-Zhi Tang*, Zhen Jin* Design, synthesis and biological activities of novel pleuromutilin derivatives with a substituted triazole moiety as potent antibacterial agents European Journal of Medicinal Chemistry, 2020, 204: Article 112604. (DOI: 10.1016/j.ejmech.2020.112604)

20.Wei Wang, Ru-Feng Yue, Zhen Jin, Li-Min He, Rong Shen, Dan Du*, You-Zhi Tang* Efficiency comparison of apigenin-7-O-glucoside and trolox in antioxidative stress and anti-inflammatory properties Journal of Pharmacy and Pharmacology, 2020, 72(11): 1645-1656. (DOI: 10.1111/jphp.13347)

21.Xiangyi Zuo, Xi Fang, Zhaosheng Zhang, Zhen Jin, Gaolei Xi*, Yahong Liu, Youzhi Tang* Antibacterial Activity and Pharmacokinetic Profile of a Promising Antibacterial Agent: 22-(2-Amino-phenylsulfanyl)-22-Deoxypleuromutilin Molecules, 2020, 25(4): 878. (DOI: 10.3390/molecules25040878)

22.陈芳，高鸿，李博，左香溢，靳珍，汤有志*. “泰妙菌素对人CYP3A4、CYP1A2、CYP2E1、CYP2D6酶活性的影响” 中国畜牧兽医 2020, 47(4): 1267-1273

23.Zhen Jin, Le Wang, Hong Gao, Ying-Hui Zhou, Ya-Hong Liu, You-Zhi Tang* Design, synthesis and biological evaluation of novel pleuromutilin derivatives possessing acetamine phenyl linker European Journal of Medicinal Chemistry, 2019, 181: Article 111594. (DOI: 10.1016/j.ejmech.2019.111594)

24.Zhao-Sheng Zhang, Yun-Zhen Huang, Jian Luo, Zhen Jin, Ya-Hong Liu, You-Zhi Tang* “Synthesis and antibacterial activities of novel pleuromutilin derivatives bearing an aminothiophenol moiety” Chemical Biology & Drug Design, 2018, 92: 1627-1637. (DOI: 10.1111/cbdd.13328)

25.Zhao-Sheng Zhang#, Yun-Zhen Huang#, Jian Luo, Bing-Feng Wang, Zhen Jin, Ya-Hong Liu, You-Zhi Tang* “Synthesis and antibacterial activity against MRSA of pleuromutilin derivatives possessing a mercaptoethylamine linker” Medicinal Chemistry, 2018, 14(6): 585-594. (DOI:10.2174/1573406414666180416131737)

26.Shao-Qing Zhang, Marco Chino, Lijun Liu, Youzhi Tang, Xiaozhen Hu, William F. DeGrado*, Angela Lombardi* “De Novo Design of Tetranuclear Transition Metal Clusters Stabilized by Hydrogen-Bonded Networks in Helical Bundles” J. Am. Chem. Soc., 2018, 140 (4): 1294–1304. (DOI: 10.1021/jacs.7b08261)

27.Zhen Jin, Yao-Zhi Yang, Jian-Xin Chen*, You-Zhi Tang* “Inhibition of pro-inflammatory mediators in RAW264.7 cells by 7-Hydroxyflavone and 7,8-Dihydroxyflavone” Journal of Pharmacy and Pharmacology, 2017, 69(7): 865-871. (DOI: 10.1111/jphp.12714) 

28.Mei-Ling Gao, Jie Zeng, Xi Fang, Jian Luo, Zhen Jin, Ya-Hong Liu, You-Zhi Tang* “Design, synthesis and antibacterial evaluation of novel pleuromutilin derivatives possessing piperazine linker” European Journal of Medicinal Chemistry, 2017, 127: 286-295. (DOI: 10.1016/j.ejmech.2017.01.004)

29.方茜，王文湘，高美玲，阳涛，刘雅红，汤有志*. “取代基团对含噻二唑片段截短侧耳素衍生物抑制鸡毒支原体活性的影响” 华南农业大学学报 2017, 38(3): 21-25 

1.汤有志，柴菲，刘雅红，靳珍.一种具有4-氨基苯硫醇侧链的截短侧耳素衍生物及其制备方法和应用，中国发明专利，专利申请号：202210505560.7

2.汤有志，刘杰，李雅军，靳珍.一种具有1，3，4-恶二唑侧链的截短侧耳素衍生物及制备与应用，中国发明专利，专利申请号：202110434606.6

3.汤有志，刘雅红，靳珍，王乐，徐子晰. 一种以2-氨基苯巯醇为连接基团截短侧耳素衍生物制备方法和用途，中国发明专利，专利申请号：201811302461.9 (2019-04-23)

4.汤有志，张昭圣，刘雅红. 一种具有2-氨基苯巯醇侧链的截短侧耳素衍生物及其制备方法和用途，中国发明专利，专利申请号：201610876597.5

5.汤有志(Tang Youzhi)，刘雅红(Liu Yahong)，张昭圣(Zhang Zhaosheng). 一种具有2-氨基苯巯醇侧链的截短侧耳素衍生物及其制备方法和用途(Pleuromutilin Derivative Having 2-Amino Phenyl Mercaptan Side Chain, Preparation Method Therefor, And Uses Thereof.) 2018, PCT Int. Appl., PCT/CN2016/101097, WO2018058534. (2018-07-02)

授权专利：

6.汤有志，李博，张广杰，刘雅红，靳珍. 一种具有1，2，4-三唑席夫碱截短侧耳素衍生物及制备与应用，中国发明专利，专利证书号：ZL202010557136.8(2021-09-24)

7.汤有志，张光雨，刘雅红，靳珍. 一种具有哌嗪及1,2,3-三氮唑仲胺侧链的截短侧耳素衍生物及制备与应用，中国发明专利，专利证书号：ZL201910610738.2(2021-05-11)

8.汤有志，张昭圣，靳珍，张光雨. 一种具有三氮唑侧链的截短侧耳素衍生物及其制备方法和应用，中国发明专利，专利证书号：ZL201911233315.X (2021-03-16)

9.汤有志，高鸿，刘雅红，张昭圣. 一种截短侧耳素类化合物及其制备方法和应用，中国发明专利，专利证书号：ZL201810718480.3 (2021-02-26)

10.Tang Youzhi, Liu Yahong, Zhang Zhaosheng. Pleuromutilin derivative having 2-amino phenyl mercaptan side chain as well as preparation method and application thereof. US10/421715B2 (2019-09-24).

11.汤有志，高美玲，刘雅红. 一种具有酰基哌嗪基侧链的截短侧耳素衍生物及其制备方法和用途，中国发明专利，专利证书号：ZL201611115910.X (2019-09-10)

12.汤有志，黄允真，刘雅红，张昭圣. 一种具有2-氨基巯醇侧链的截短侧耳素衍生物及其制备方法和用途，中国发明专利，专利证书号：ZL201610880615.7 (2019-09-03)

13.汤有志，王文湘，刘雅红，方茜. 一类具有硫醚侧链的截短侧耳素化合物及其制备方法和用途，中国发明专利，专利证书号：ZL201610472526.9 (2019-02-12)

14.汤有志，刘雅红，陈良柱. 一种盐酸沃尼妙林肠溶性固体分散体及其制备方法与应用，中国发明专利，专利证书号：ZL201310750979.X (2015-09-30)

15.DeGrado William F.; Sheppard Dean; Jo Hyunil; Reed Nilgun Isik; Tang Youzhi; Mcintosh, Joel. Anti-alphavbeta1 integrin inhibitorss and methods of use. US10214522B2 (2019-02-26)

16.DeGrado William F.; Sheppard Dean; Jo Hyunil; Reed Nilgun Isik; Tang Youzhi. Anti-alphavbeta1 integrin compounds and methods. US10131658B2 (2018-11-20)

17.刘雅红，汤有志. 一种截短侧耳素类抗生素的制备方法，中国发明专利，专利证书号：ZL201110163945.1

18.刘雅红，汤有志，骆健，傅晓华. 一种乙酰甲喹代谢产物脱二氧乙酰甲喹的制备方法，中国发明专利，专利证书号：ZL201210487218.5

19.刘雅红，骆健，汤有志，廖晓萍，孙坚. 一种具有哌嗪侧链的截短侧耳素衍生物及其制备方法和用途，中国发明专利，专利证书号：ZL201610240920.X

刘雅红，黄青山，方炳虎，付光武，陆婉英，廖晓萍，陈建新，张继恩，陈良柱，吴强三，丁焕中，孙永学，汤有志，孙坚，兽用原料药物和制剂的研制与应用，2014年广东省科学技术奖一等奖，证书号：B02-1-1-01-R13

兴趣是最好的老师。